The Noble journey part I with Randy Schekman

This is first part of the conversation with Randy Schekman. He is an investigator of the Howard Hughes Medical Institute and a Professor of Cell and Developmental Biology in the Department of Molecular and Cell Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his role in revealing the machinery that regulates the transport and secretion of proteins in our cells. He shares the prize with James E. Rothman of Yale University and Thomas C. Südhof of Stanford University.

In this conversation we talk about his early career, membranes, exosomes, scientific publishing and Elife journal.

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00:00:00 Introduction

00:01:08 Interest in microbes

00:05:27 Yeasts have feelings too!

00:06:24 What was already known about vesicular trafficking?

00:08:42 How do you envision a cell?

00:09:51 Your work to understand 'what is life'?

00:12:48 Formation of membranes for the origin of life

00:14:39 Why membranes are ideal for life!

00:15:48 Differences of membranes

00:17:07 The evolution of membranes

00:19:02 Starting the work on vesicular trafficking

00:23:09 Discovery of COPII complex

00:25:24 The specialty of COPII complex

00:26:30 Importance of vesicular trafficking for animal physiology

00:27:39 Understanding of gut feeling!

00:28:56 What has changed after Nobel prize?

00:30:30 Different cellular trafficking system

00:32:11 Exosomes and miR223

00:34:29 Problems with exosomes as therapeutics

00:35:08 Peer-review and scientific publishing

00:39:44 Genesis of Elife

00:44:05 Impact factor of Elife

00:46:35 Thank you!

More Talks from Randy:

TEDx on scientific publishing:


Nobel prize inspiration initiative lecture: