Evolutionary origins of viruses and cellular life with Eugene Koonin
This episode is with Eugene Koonin. He is a highly respected computational biologist who has made significant contributions to the fields of evolutionary biology, genomics, and bioinformatics. Eugene is a distinguished investigator at the National Center for Biotechnology Information (NCBI). His research interests include the evolution of viruses and the development of new computational methods for analyzing large-scale genomic data. Here we talk about origins and evolution of viruses, major transitions in evolution, diversity of viruses, and tools to study viruses.
Follow Reason with Science:
00:01:03 How do we define viruses?
00:04:12 Major transitions in evolution and viruses
00:10:15 Last Universal Common Ancestor (LUCA) and its virome
00:15:50 Diversity of viruses
00:26:40 Multiple origins of viruses
00:28:56 Origin of viruses
00:35:21 Viruses and replicators
00:38:11 Selfish elements as information carriers
00:40:01 Nature of selfish elements
00:42:45 Why selfish elements emerge?
00:47:46 Membranes of viruses
00:53:00 Connection between information and compartments
00:56:10 Replication strategies of selfish elements
00:58:33 Strategies of viruses to organize and replicate their genomes
01:00:18 Genomes of giant viruses
01:02:56 Small or Giant viruses: which came first?
01:03:34 Tools to study phylogenetics of viruses
01:06:40 Can we identify the host of a virus from the genome and vice versa?
01:08:39 Minimum number of genes required for the survival
01:12:55 Understanding the complexity of alien life forms
01:14:31 Last Bacterial Common Ancestor (LBCA) and Last Archaeal Common Ancestor (LACA)
01:18:56 Evolution of Last Eukaryotic Common Ancestor (LECA) from bacterial and archaea
01:23:02 Endosymbiosis in nature
01:26:15 Bacterial and Archaea emdosymbiosis effects on compartments
01:28:27 Size differences in bacteria and archaea
01:29:33 Future of phylogeny of viruses
01:31:20 Thank you!
Music by: Ahmed Hassan (https://www.youtube.com/@2ays577/featured)